منابع مشابه
Treatment of Hypertension: Monotherapy or Combination Therapy Monotherapy In Hypertension
Is there a place for monotherapy? Yes, there is a place for monotherapy. According to the Seventh report of the Joint National Committee in 2003 (1) and the European guidelines from 2007 (2) and 2009 (3), the first step in hypertension control is changing lifestyle before initiating medical treatment. According to the baseline blood pressure and the presence or absence of target organ damage an...
متن کاملClonidine monotherapy in mild hypertension.
In our study of adolescents with sustained hypertension, single-agent therapy with clonidine significantly reduced blood pressure and heart rate, while hydrochlorothiazide as a single agent significantly reduced only systolic pressure. After 24 weeks of therapy, 40 percent of the diuretic-treated group achieved the treatment goals vs 87 percent in the group treated with clonidine. No alteration...
متن کاملLong-term outcomes with ambrisentan monotherapy in pulmonary arterial hypertension.
BACKGROUND This study evaluated long-term outcomes in patients with pulmonary arterial hypertension (PAH) undergoing treatment with ambrisentan monotherapy, a selective oral endothelin-1 receptor antagonist. METHODS AND RESULTS Patients who participated in the Ambrisentan in Pulmonary Arterial Hypertension: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Multicenter Efficacy Study (AR...
متن کاملOnce daily felodipine monotherapy in mild to moderate hypertension.
In a single-blind study conducted at our centres, 78 hypertensive patients were enrolled with 58 completing the study according to the protocol. Mean supine and standing blood pressures were significantly reduced after treatment with felodipine, reductions being 27/21 mmHg (p < 0.0001) and 25/19 mmHg (p < 0.0001) respectively. Of 46 patients given felodipine 5 mg, 44 (95.7%) achieved target blo...
متن کاملUse of clonidine and propranolol as monotherapy in borderline hypertension.
The effect of clonidine (average 0.24 mg/day) and propranolol (average 105 mg/day) on home blood pressure readings in 16 patients with borderline hypertension was investigated in a randomized, double-blind, placebo crossover design. Patients could detect small but significant decreases of blood pressure with both active compounds (-8/-5 with propranolol and -11/-7 with clonidine). The larger me...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1984
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1984.tb02456.x